PTEN and Familial prostate cancer: IPA identified the top 5 canonical pathways associated with the miRNA signature and downstream molecules as PTEN signaling (p-value 3.64E-09), prostate cancer signaling (p-value 1E-07), pancreatic adenocarcinoma signaling (p-value 2.83E-07), PI3K/AKT signaling (p-value 5.15E-07), and molecular mechanisms of cancer (p-value 1.02E-6) (S3 Fig., S1 Table).