Taken together, these findings demonstrate that in addition to the previously characterized CTED1, CTED2, CTED5 and CTED8 mutants found in GBM and lung cancer, other EGFR truncated mutants produced by different intragenic deletions of C-terminal domain are able to induce cellular transformation in NIH-3T3 cells. Here, EGFR is linked to glioblastoma.