EGFR and glioblastoma: In contrast, EGFR alterations identified in GBM include intragenic deletions targeting exons 2 to 7 deletion (known as EGFR vIII), exons 14 to 15 (known as EGFRvII) and somatic mutations within the extracellular domain of EGFR, but kinase domain mutations are relatively rare [12-16].