Intriguingly, we found that cells expressing GBM-derived CTED1 mutant exhibited the highest sensitivity to three of the EGFR inhibitors (afatinib, dacomitinib, and cetuximab) whereas cells expressing GBM-derived CTED5 mutant exhibited the lowest sensitivity in two of the tested inhibitors (afatinib and dacomitinib). Here, EGFR is linked to glioblastoma.