In another study, it has been found that loss of the p53 tumor suppressor gene leads to the dedifferentiation of mouse hepatocytes into Nestin-positive progenitor-like cells, and these progenitor-like cells could be differentiated into HCC by activated Wnt/β-catenin or CCA by activated Notch signaling, respectively [34]. The gene discussed is TP53; the disease is hepatocellular carcinoma.