We reported that stabilization of Bcl-2 protein via phosphorylation of Bcl-2 at Serine 87 (pBcl-2-S87) by PXN-mediated ERK activation conferred 5-fluorouracil (5-FU) resistance and an unfavorable response to 5-FU-based chemotherapy in colorectal cancer patients [13]. Here, BCL2 is linked to colorectal cancer.