PTPRO and metabolic dysfunction-associated steatohepatitis: Compared with WT-NASH mice, ptpro−/− mice exhibited a significant increase in the levels of p-PI3K, p-AKT, and p-s6k, suggesting that activated Akt (S473) rather than AKT (T308) signaling results in autophagy deficiency and aberrant lipogenesis, which in combination promote hepatocarcinogenesis.