This study advanced previous findings and defined that increased proliferation and migration conferred by Mer overexpression are primarily dependent on MAPK and FAK signaling pathways, respectively as blockade of MAPK and FAK signaling pathways abrogated the increased proliferation and migration in Mer-overexpressed lung epithelial cells and NSCLC cells, respectively. The gene discussed is MERTK; the disease is non-small cell lung carcinoma.