Moreover, a recent study demonstrated that inhibition of Akt and Pim kinases synergistically inhibited mTORC1 signaling and Mcl-1 expression to induce apoptosis in various AML cells, although neither the synergistic effect nor expression levels of Pim kinases correlated with the presence of FLT3-ITD [43]. This evidence concerns the gene AKT1 and acute myeloid leukemia.