Since HOXB13 is involved in both positive and negative growth control through activation of AKT/mTOR signaling [44] and inhibition of CCND1 [14], it is possible that the association between HOXB13 expression and PTEN deletion reflects compensatory up regulation of HOXB13 in cancer cells with severely deregulated AKT signaling. The gene discussed is PTEN; the disease is cancer.