Since HOXB13 is involved in both positive and negative growth control through activation of AKT/mTOR signaling [44] and inhibition of CCND1 [14], it is possible that the association between HOXB13 expression and PTEN deletion reflects compensatory up regulation of HOXB13 in cancer cells with severely deregulated AKT signaling. This evidence concerns the gene CCND1 and cancer.