CREB1 and metastatic malignant neoplasm in the lymph nodes: More interestingly, we found that CREB1 expression in cancerous tissues with lymph node metastasis (LNM) was significantly higher than that in cancerous tissues without LNM (Figure 1D–1I; Figure 2B, t-test; P < 0.05), suggesting that CREB1 may be associated with lymph node metastasis in gastric cancer.