In order to determine the diagnostic value of CREB1 in gastric cancer, receiver operator characteristic (ROC) curves were constructed and the area under the curve (AUC) was calculated to assess the ability of CREB1 expression (IHC sum scores) to differentiate between cancerous cases and nontumorous cases, or cancerous tissues with LNM and cancerous tissues without LNM. This evidence concerns the gene CREB1 and gastric cancer.