IDH1 and neoplasm: Our data demonstrated that the tumor volumes in nude mice injected with HT1080/IDH1+/− cells re-expressing IDH1-R132C were significantly larger than those from mice injected with HT1080/IDH1+/− cells re-expressing IDH1-R132C/T77A double mutant (Tumor size at 25 days: 204 ± 33 mm3 vs. 67 ± 25 mm3 for IDH1-R132C vs. IDH1-R132C/T77A; p = 0.0045) (Figure 5C).