Since CD4+ T cells are also known to play a role in orchestrating antibody production and the activation and expansion of CD8+ T cells [28], and increasing evidence has shown that CD4+ T cells can significantly contribute to tumor suppression in vivo [29,30], in the present investigation, we evaluated whether CD8+ and CD4+ T-cell proliferation activities could also be affected by vaccination with Cp, Am or [Am+Cp]-treated, TCL-loaded DCs. Here, CD4 is linked to neoplasm.