By multivariate analysis, low BECN1 expression was significantly associated with shortened survival, even after adjustment for BRCA1 expression, age, tumor grade, tumor size, stage, intrinsic subtypes, TP53 mutation and treatment (hazard ratio 0.6 [0.4–0.9], P = 0.02) (Table 3). This evidence concerns the gene BRCA1 and neoplasm.