TP53 and breast neoplasm: In the METABRIC dataset (Supplementary Table 4), low BECN1 expression was associated with basal-like breast tumors (odds ratio 5.6 [95% CI 3.4 to 9.6], P = 5.5E− 13), HER2-enriched breast tumors (odds ratio 4.1 [95% CI 2.5 to 6.7], P = 8.8E− 10), tumors with TP53 mutation (odds ratio 2.3 [95% CI 1.1 to 4.9], P = 0.017), and grade III tumors (odds ratio 3.4 [95% CI 1.5–8.5], P = 0.002).