CD8A and neoplasm: Furthermore, we demonstrated that although MAGE A3 has been related to some features of tumor aggressiveness, when tumors were MAGE A3+ and able to recruit CD8+ expression, aggressiveness not only disappeared but also was associated with better prognostic features such as stage I, smaller tumors (<2 cm), younger age (≤45 years), and absence of extrathyroidal invasion.