POMC and cholestasis: In addition to obesity, patients with POMC mutations displayed hypocortisolism, hair and skin hypopigmentation, neonatal hypoglycemia, seizures, cholestasis and voracious appetite (Farooqi et al., 2006; Krude et al., 1998; Krude et al., 2003).The hypopigmentation of the hair and skin is not always observed in non-European populations, and POMC mutations should still be considered in individuals with severe early onset obesity even if typical pigmentary phenotype is missing (Cirillo et al., 2012; Clément et al., 2008; Mendiratta et al., 2011).