Exon sequencing revealed a deleterious non-synonymous variant (p.R270H) of minor allele frequency (MAF) of 3% that inhibits GPR120 signaling activity and increases the risk of obesity by 62% in 6,942 obese individuals and 7,654 control subjects from Europe (Ichimura et al., 2012). This evidence concerns the gene FFAR4 and obesity due to melanocortin 4 receptor deficiency.