SH2B1 and Obesity: Table 2 provides a summary of these identified genes and associated SNPs. Interestingly, GWAS showed that almost all genes involved in Mendelian forms of obesity in mice and humans (LEPR, POMC, MC4R, BDNF, PCSK1, TUB, NTRK2, SH2B1) display common variants associated with BMI and polygenic obesity as well (Dickson et al., 2010).