The role of FTO as an important contributor to polygenic obesity was confirmed in GWAS for type 2 diabetes, BMI, early onset obesity, and incidentally in a population stratification approach (Dina et al., 2007; Frayling et al., 2007; Hinney et al., 2007; Scuteri et al., 2007). The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.