PEMT and atherosclerosis: Mice genetically deficient in phosphatidylethanolamine-N-methyltransferase, an enzyme involved in hepatic PC synthesis, are protected from developing atherosclerosis [95], whereas dietary supplementation with either carnitine, γ-butyrobetaine, choline or TMAO increases atherosclerotic plaque formation in mice genetically susceptible to atherosclerosis [91-93].