Indeed, dysregulated cyclin D1 signaling during the G1 phase of the cell-cycle causes reduced chondrocyte proliferation in a mouse model of diastrophic dysplasia due to a p.A386V substitution in the eighth transmembrane domain of solute carrier family 26 member 2 (Slc26a2) (32). The gene discussed is SLC26A2; the disease is dysplasia.