IGF1R and neoplasm: Patients with positive expression of VEGF-A, IGF-I and IGF-IR experienced poorer outcomes in terms of OS (P=0.001, P=0.012 and P=0.012, log rank, respectively) and those with positive expression of four studied markers were associated with reduced DFS (Fig. 5 and Fig. 6) A univariate analysis demonstrated that reduced OS was associated with TNBC (P=0.003), high serum levels of VEGF-A (P=0.003), IGF-I (P=0.03), IGF-IR (P=0.02), large tumor size (P=0.007), and lymph nodes metastasis (P=0.004) in the overall population (Table VI).