Reduced DFS was significantly associated with high serum levels of VEGF-A, TGF-β1, IGF-IR (P<0.001) and IGF-I (P=0.003), high tumor grade (P=0.01; tumor grade indicates the aggression of the tumor), lymph nodes metastasis (P=0.004) and large tumor size (P=0.008; Table VI). This evidence concerns the gene IGF1 and neoplasm.