In this study, though we demonstrated the synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated myocardial fibrosis after MI, we failed to reveal the underlying mechanisms of Ang II-induced synergistic effects of the TGF-β1 and HIF-1α signalling pathways. Here, TGFB1 is linked to Myocardial fibrosis.