FLT3 and acute myeloid leukemia: Similarly, Grosjean-Raillard et al. reported that constitutive activation of FLT3 signaling resulted in activation of NF-κB, while inhibition of FLT3 signaling either by small molecule inhibitor or knockdown of Flt3 with RNAi reduced NF-κB activity and induced apoptosis in AML cell lines and CD34+ primary AML cells [83].