KRAS and familial pancreatic carcinoma: In addition, if Snail is elevated by several triggers (For example; activation of TGF-β signaling [29, 30], RKIP reduction in MPM or K-Ras activation in pancreatic cancer [25]), the interaction of RKIP and NF2 (Figure 6E) would be disrupted and p53 is suppressed (Figure 7).