Some diagnostic criteria of HE have been proposed as a combination of neurological and/or psychiatric symptoms, elevated serum anti-thyroid antibodies [Abs] (anti-thyroglobulin [TG] Abs and/or anti-thyroid peroxidase [TPO] Abs) and responsiveness to steroid, associated in part with abnormal EEG, normal brain imaging and elevated proteins in CSF [7, 66]. The gene discussed is TPO; the disease is hereditary elliptocytosis.