As expected, knockdown of endogenous Shp2 markedly suppressed tumor growth, and re-expression of Shp2WT dramatically increased tumor growth while Shp2−K590R did not affect (Figure 3E, Supplementary Figure S3B), which were consistent with soft agar results gotten from stable HepG2 cell lines (Figure 3D). This evidence concerns the gene PTPN11 and neoplasm.