The interaction of ANO1 and EGFR could foster the localization of EGFR to membrane regions proximal to intracellular calcium stores, favoring the calcium-dependent binding of Calmodulin to the JMD and ligand-dependent activation of EGFR, in addition to activation by other calcium activated kinase, like protein kinases protein kinase C. This model is further supported by our findings that knockdown of ANO1 reduces the phosphorylation of calmodulin-dependent kinases (CAMK) in breast cancer [33]. Here, ANO1 is linked to breast carcinoma.