ANO1 is amplified and highly expressed in a large subset of HNSCC tumors, as well as in a variety of other carcinomas including breast cancer, prostate carcinoma, glioblastoma, GIST (gastrointestinal stromal tumor) and ESCC (esophageal squamous cell carcinoma) [31–37]. The gene discussed is ANO1; the disease is esophageal squamous cell carcinoma.