Because of the elevated AKT, ERK1/2 and p38 phosphorylation levels in shear stress-, forskolin- and IL-1β-stimulated chondrosarcoma cells, we examined the potential contributions of AKT, ERK1/2 and p38 to regulating the activities of c-Jun and NF-κB. The gene discussed is MAPK14; the disease is chondrosarcoma.