ADCY1 and chondrosarcoma: Interestingly, the adenylate cyclase inhibitor SQ22536 or an anti-IL-1β antibody alone were effective in suppressing the shear-induced upregulation of AKT, ERK1/2 and p38 phosphorylation, which result in MMP-7 suppression in shear-activated SW1353 chondrosarcoma cells (Fig. 2A).