In addition, incubation of SW1353 cells with LY294002 (10 μM), U0126 (10 μM) or SB203580 (10 μM) abolished both forskolin- and IL-1β -dependent MMP-7 upregulation (Figs. 2D, 2E), which is attributed to the ability of these inhibitors to selectively suppress the phosphorylation of AKT, ERK1/2 or p38 in human chondrosarcoma cells (Figs. 2D, 2E). This evidence concerns the gene MMP7 and chondrosarcoma.