In light of our previous work showing that exposure of human chondrocytes to fluid shear stress transactivates the NF-κB p65 subunit [59, 60] and given that the expression of MMP-7 may be dependent on NF-κB [61], we evaluated the potential role of the NF-κB pathway in MMP-7 induction in human chondrosarcoma cells. The gene discussed is MMP7; the disease is chondrosarcoma.