Hypomethylation of the Ptch promoter in RMS is most likely established independently of the tumor-specific expression profile of epigenetic modifier enzymes, because RMS i) generally express elevated levels of genes involved in the establishment and maintenance of genomic hypermethylation (i.e. HDACs and Dnmts; see Fig. 3) and ii) do not exceedingly express genes associated with the regulation of H3K4 methylation. Here, PTCH1 is linked to neoplasm.