Of note, the methylated status of Ndrg2 significantly correlated with some clinicopathological parameters in GC: H. pylori (HP) infection (P=0.000), tumor size (P=0.001), venous invasion (P=0.000), lymphatic involvement (P=0.000), invasive depth (P=0.000), lymph node metastasis (P=0.000), distant metastasis (P=0.000) and clinical stage (P=0.000). The gene discussed is NDRG2; the disease is metastatic malignant neoplasm in the lymph nodes.