RAB3D and neoplasm: In addition, there were no obvious differences of cell proliferation in vitro (Fig. S5A and S5B) and tumor growth in vivo (Fig. S5C-F) among different groups, although the overexpression of Rab3D decreased apoptosis to some extent (Fig. S5G), demonstrating that Rab3D is highly specific for promoting tumor invasion and metastasis but not due to changes in proliferation.