Similar to the reported 7.7% allele frequency in Chinese colorectal cancer patients [30], we found an incidence of MLH1 V384D around 7-8% in tumors with wild-type or L858R mutant EGFR, suggesting that MLH1 V384D may not be a mutation secondary to the EGFR L858R mutation. This evidence concerns the gene MLH1 and colorectal cancer.