Because integrin-mediated focal adhesion signaling pathway can influence various processes of tumor cells proliferation, adhesion, invasion and migration, we detected six major groups of proteins including integrin α6, integrin β1, FAK, Src, paxillin and PTEN to detect the effect of UA/US597 on integrin-mediated focal adhesion signaling pathway. The gene discussed is PTK2; the disease is neoplasm.