In summary, the present study for the first time demonstrated that UA and its novel derivative US597 were able to suppress cell surface adhesive molecules including ICAM-1, VCAM-1, E-selectin and P-selectin proteins expression, and further target integrin α6β1-mediated focal adhesion signaling pathway (Figure 9), and resulted in inhibiting adhesion and migration of cancer cells in vitro and in vivo. This evidence concerns the gene SELP and cancer.