TIMP3 and cancer: A total of 73 genes were significantly upregulated in these samples including a subset of known cancer-related genes such as IL8 [7], the heat shock proteins HSPA1A/HSPA1B* and HSPA6 [8], the tumor suppressor TFPI2, SEMA3E that is involved in tissue development and cell adhesion [9], the cell cycle regulator MAGEC2/MAGEC3 [10], EYA4 which expression is altered in hepatocellular cacinoma, the protease inhibitor and tumor promoter Serpine 1 [11, 12], the matrix metaloprotease inhibitor TIMP3 [13], and the melanoma cell adhesion molecule MCAM [14] (Supplementary Table S1).