Although the function of EZH2 is still unclear, recent research revealed that phosphorylation of EZH2 at serine 21 (pS21 EZH2) by AKT facilitates STAT3 methylation by EZH2 and enhances STAT3 activity, which is necessary to maintain GBM stem-like cell self-renewal and tumor malignancy [48]. This evidence concerns the gene AKT1 and glioblastoma.