E-cadherin was reported to cross-talk with ZEB1 [28], NF-κB [29] and twist1 [30], and we validated that Lenti-HOTAIR si treatment led to a decrease in the expression of ZEB1, NF-κB and twist1 in GBM and MCF-7 cells. The gene discussed is NFKB1; the disease is glioblastoma.