CTNNB1 and neoplasm: A hallmark of active β-catenin signaling in the tumor is the accumulation of β-catenin both in the cytoplasm and nucleus irrespective of the mutational status of CTNNB1. Firstly, we examined the cellular localization of β-catenin in a normal human adrenal gland, a human adrenal carcinoma and xenografted tumors formed by transplantation of H295R cells beneath the kidney capsule of Scid mice.