Furthermore, when co-transfected with PTEN-, PHLPP2-, or FOXO3-3′UTR dual luciferase reporter plasmid, together with miR-93, miR-93 inhibitor or negative control, into the glioma cells, as shown in Figure 3C, miR-93 led to a consistent reduction of luciferase activity of PTEN, PHLPP2, FOXO3 reporters. The gene discussed is FOXO3; the disease is central nervous system cancer.