FOXO3 and central nervous system cancer: Herein, we found that miR-93 was significantly upregulated in gliomas, and overexpressing miR-93 activated PI3K/Akt signaling through downregulating PTEN, PHLPP2 and FOXO3 expression via targeting their 3′UTRs, subsequently resulting in glioma cell proliferation and progression (Figure 7).