48 out of 90 selected differentially expressed genes were confirmed by qRT-PCR, including genes implicated in neuroinflammation, neurodegeneration and cognitive disorders (e.g., up regulation of SEPP1, APOE, DAB2, CD163, CXCL12, VWF and down-regulation of HAND1, OSR1) (p<0.05). The gene discussed is SELENOP; the disease is Cognitive impairment.