IL-18 gene (-137G/C) promoter polymorphism has been associated with susceptibility to several diseases like CAD [32], Type 1 diabetes [33,34], rheumatoid arthritis [35,36], sarcoidosis [37], atopic eczema [38], adult-onset Still’s disease [26], and seasonal allergic rhinitis[24]. This evidence concerns the gene IL18 and coronary artery disorder.