Apart from these aforementioned in vitro studies that have demonstrated the ability of T cells to inhibit liver-stage malaria parasites, two other experimental findings in murine models highlight the importance of CD8+ T cells: (i) adoptive transfer of CD8+ T cell clones specific for TRAP or CSP can induce protection against P. berghei and P. yoelii in naive mice [39–42] and (ii) depletion of CD8+ T cells completely abolishes the protection seen in radiation and genetically attenuated sporozoite models [24, 43–46]. This evidence concerns the gene CD8A and malaria.