Soft tissue sarcomas: Assessment of the association of E-cadherin expression and 5-year overall survival in STS cases resulted in a pooled OR of 4.047 (95% CI: 2.127–7.700; Z = 4.26; P = 0.000; Fig 3), indicating that the loss of E-cadherin was significantly associated with poorer prognosis in STS. This evidence concerns the gene CDH1 and telomere syndrome.