It is also known to suppress cyclin D1 activities by interacting with beta-catenin and HDAC1, thus, leading to a decrease in acetylated H3 and H4 at the cyclin D1 promoter.35 SOX6 is misexpressed in the tumor subtypes though it is unknown if it works in conjunction with MDM2 to promote these processes. This evidence concerns the gene MDM2 and neoplasm.