In contrast, there was no appreciable difference for any of these proteins, when we compared malignant vs. benign tumors, without distinguishing and grouping the samples into oncocytic or non-oncocytic (3.5±0.2 vs. 3.0±0.3, p = 0.31 for Mfn2; 2.8±0.2 vs. 2.3±0.4, p = 0.28 for Opa1; 3.8±0.2 vs. 3.5±0.4, p = 0.48 for Drp1; 4.1±0.1 vs. 3.9±0.34, p = 0.71 for Fis1) (Fig 2B). This evidence concerns the gene OPA1 and benign neoplasm.