The current data demonstrate highly significant increases in all Th17 pathway-associated chemokines and cytokines measured in the airways of adult bronchiectasis subjects, including pathway effectors (IL-17A, IL-6, IL-8 and TNF-α) and regulators (IL-1α, IL-1β, IL-6 and IL-23). The gene discussed is CXCL8; the disease is bronchiectasis.