Along these lines, GSK3β inhibitors are effective in reducing the growth and chemotherapeutic resistance of several non-ARMS cancer cells40 and suppresses growth and renewal of embryonal RMS tumors.24 Even more important for potential clinical applicability, small molecule inhibitors of GSK3β, such as lithium chloride and Tideglusib, were proven to be non-toxic in animal models and humans, and are useful for treating a wide range of cancers, including ovarian, colorectal, neuroblastoma and prostate.41, 42, 43, 44, 45. This evidence concerns the gene GSK3B and neuroblastoma.