CXCR4 and familial pancreatic carcinoma: Given that 1/Akt is a downstream target of the CXCR4-SDF-1α axis [30] resulting in enhanced proliferation of pancreatic cancer cells [31] and 2 /that Akt has been associated with chemoresistance of pancreatic cancer [32] we have determined the Akt phosphorylation state in MiaPaCa-2 cells following incubation with SELN6.0 for time up to 96h.