Although the SDF-1α-CXCR4 and SDF-1α-CXCR7 axes were each involved in cancer cell survival [28, 29] we showed here that 1 / CXCR4 is the main represented receptor for the α-chemokine SDF-1α on MiaPaCa-2 cell membranes. The gene discussed is ACKR3; the disease is cancer.