Since it has been reported that GLP-1 receptor was not detected in glomerulus [7] and we were also able to detect neither GLP-1 receptor nor GIP receptor both in glomerulus and cultured podocyte (Supplemental Figure 2: expression of GLP-1 receptor and GIP receptor were evaluated by RT-PCR), incretin independent pathway might have roles in protecting against DN. The gene discussed is GLP1R; the disease is liver dysplastic nodule.