TLR4 and Sepsis: Furthermore, mammalian toll-like receptors (TLR)-dependent pathway is also found to involve in the process of sepsis-induced apoptosis, which was confirmed by several studies: (i) apoptosis of spleen DCs from CLP performed on TLR4−/−, TLR2−/−, and TLR2−/− TLR4−/− was inhibited [31].