TLR4 and Sepsis: When DCs were stimulated with TLR2 agonist (Pam3Cys) or TLR4 agonist (LPS) or TLR9 agonist (CpG-DNA), mRNA levels of both Il12 p40 and Il12p35 from sepsis splenic DCs were significantly lower than that from sham splenic DCs [30].