In addition to the aforementioned pathways, hyperglycaemia-induced oxidative stress also triggers other multiple, interconnected signal transduction cascades including poly-ADP ribose polymerase (PARP) induction [75, 76], mitogen activated protein kinase (MAPK) overactivation [77, 78], calcium signaling [79], growth factors induction, phosphoinositide pathway, and stimulating the enzymes of arachidonic acid metabolism [80–82] which are all involved in the pathogenesis of diabetic neuropathy. Here, WNK2 is linked to Hyperglycemia.