PKC activation is relevant to nerve function and the pathogenesis of diabetic neuropathy probably through triggering an intracellular signaling cascade resulting in the elevation of the expression of transcription factors like NF-κB, proinflammatory cytokines like transforming growth activator beta (TGFβ), blood clotting inhibitors like plasminogen activator inhibitor (PAI), and extracellular matrix proteins [72, 73]. This evidence concerns the gene PRRT2 and diabetic neuropathy.