INS and obesity due to melanocortin 4 receptor deficiency: The beneficial effects of Gly in obesity and T2DM therapy can result from improved insulin sensitivity [38], increased anti-inflammatory capacity [39], and normalization of secretion of triacylglycerol-rich very low density lipoproteins from the liver by triggering neuronal transmission in the dorsal vagal complex through the N-methyl-D-aspartate receptor [40].