Moreover, a number of Atg genes, such as Beclin 1 and LC3 genes, map to chromosomal loci that are frequently monoallelically deleted in PCa cells [35, 36] and the protein expression of Beclin 1 ad LC3 have been demonstrated to be lower in prostate adenocarcinoma than in prostate benign hyperplasia [37]. This evidence concerns the gene MAP1LC3A and benign prostatic hyperplasia.