SIRT1 and posterior cortical atrophy: Consistently with the in vitro findings, treatment of 4- or 5-week-old PTEN knockout mice with resveratrol for 14 weeks was associated with reduction in the prostatic levels of mTORC1 activity and increased expression of SIRT1, supporting that the SIRT1/S6K pathway could play an important role in autophagy induced by resveratrol in PCa [46].