Gossypol (10 μM) preferentially induced apoptosis in PCa cells with low Bcl-2 (LNCaP, DU145 and C4-2B), whereas an autophagic cell death was observed in apoptosis-resistant, androgen independent cells with high Bcl-2 (PC-3 and CL-1) [49]. The gene discussed is BCL2; the disease is posterior cortical atrophy.