ERBB2 and breast adenocarcinoma: Based on the increased level of anti-neoplastic cytotoxicity that can potentially be gained through dual simultaneous selectively targeted” epirubicin delivery at trophic receptors over-expressed (EGFR) and highly over-expressed (HER2/neu) by chemotherapeutic resistant mammary adenocarcinoma (SKBr-3) [16] the concept of this molecular strategy does have therapeutic merit.