HMGCR and cancer: Excessive accumulation of cholesterol within cells could be either due to increased LDL-cholesterol internalization because of high expression of low density lipoprotein receptor (LDLR), and/or due to increased synthesis of cholesterol inside cancer cells because of high activity of HMGCR, and/or inhibition of cholesterol efflux due to deficiency or inactivation of ATP-binding cassette (ABC) transporter proteins such as ABCA1 and ABCG1 [17,20].