These results indicated that compared to Stat3 and Akt, the stabilization of Bcr-Abl and Jak2 are more dependent on HSP90, suggesting the crucial role of HSP90 in protecting Bcr-Abl and Jak2 from degradation in CML cells. This evidence concerns the gene AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive.